74th Mosbacher Kolloquium
"Immune Engineering - from Molecules to Therapeutic Approaches"
Mosbach/Baden
March 23 - 25, 2023
Welcome
Dear Friends and Colleagues,
The traditional spring meetings of the German Society for Biochemistry and Molecular Biology (GBM) are held annually in the picturesque town of Mosbach to promote the exchange of scientific ideas, discuss emerging themes and to foster the education of young scientists.
The scientific theme of the 74th meeting is „Immune Engineering – from Molecules to Therapeutic Approaches“.
Harnessing the power of our immune system is currently emerging as the most promising avenue for previously uncurable diseases. Antibodies remain the mainstay of immune therapy and still hold major opportunities for the future. Engineering immune cell communication by tailor-made cytokines or directly editing the cells of our immune system as living drugs are exciting current developments in the field.
The Mosbacher Kolloquium in 2023 will bring together academic and industrial leaders in these fields. This will allow to obtain an overview over the state-of-the-art but also chart future developments in basic science and clinical translation.
We will provide a platform for fruitful scientific exchange of ideas that helps inspiring young scientists in their future research endeavors in this rapidly developing field.
We wish all of you a wonderful conference, lively exchange and fruitful contacts.
Matthias Feige
Dorothee Ambrosius
Christian Klein
Dirk Busch
Programm
16:00 - 19:45
Arrival and registration
18:00 - 18:30
Brief Introductory lecture („Primer“)
A short intro on immune therapy and engineering - aimed at undergraduates/graduate students
(delivered by the organizers)
20:00
Welcome reception
by the Lord Mayor of Mosbach and the president of GBM
(City hall of Mosbach)
08:50
Opening remarks
09:00 - 12:00
Session 1:
Next generation antibody-based immunotherapies (Novel concepts: The scientific basis)
(Chairs: Dorothee Ambrosius & Christian Klein)
David Ho /New York [USA]
Antibody Evasion Properties of SARS-CoV-2 Variants
09:30 - 09:45
Early career investigator talk 1
Marlitt Stech /Potsdam [DE]
Design and generation of antibody-drug conjugates using non-canonical amino acids
09:45 - 10:15
Harald Kolmar /Darmstadt [DE]
Immune-Cell Engagement in Tumour Therapy: From Bispecific to Multispecific Antibodies
10:15 - 10:45
Coffee break
Mark Cragg /Southampton [UK]
Engineering antibodies for immune stimulation
11:15 - 11:30
Early career investigator talk 2
Leonie Kolmar /Lausanne [CH]
Droplet microfluidic antibody screening platform for functional antibodies at the single-cell level
11:30 - 12:00
Adi Barzel /Tel Aviv [IL]
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice
12:00 - 13:00
Lunch break
13:00 - 14:30
Poster session 1
(even poster numbers)
14:30 - 16:45
Session 1 (continued):
Next generation antibody-based immunotherapies (Novel concepts: Application in the clinic)
(Chairs: Dorothee Ambrosius & Christian Klein)
17:15 - 19:30
GBM General Meeting
(for GBM members only!)
20:30 - 21:45
Lynen Reception & Poster session 2
(all poster numbers)
22:00 - 24:00
Get Together & Networking
(organized by the Junior GBM)
09:00 - 12:00
Session 2:
Engineering cytokines and their receptors
(Chair: Matthias Feige)
Martin Oft /Menlo Park [USA]
Engineering IL-2 to increase anti-tumor efficacy and mitigate capillary leak
09:30 - 09:45
Early career investigator talk 4
Lucia Bonati /Lausanne [CH]
Leveraging chemically-controlled protein switches for increased safety of cytokine-based cancer immunotherapeutics
09:45 - 10:15
Jürgen Scheller /Düsseldorf [DE]
Synthetic cytokine signaling
10:15 - 10:45
Coffee break
Li Tang /Lausanne [CH]
Metabolic reprogramming of exhausted T cells by IL-10 enhances anti-cancer immunity
11:15 - 11:30
Early career investigator talk 5
Puyan Rafii /Düsseldorf [DE]
Engineering of synthetic cytokine chimeras (cytokimeras)
11:30- 12:00
Sebastian Kobold /Munich [DE]
Arming T cells with chemokine receptors for cancer therapy
12:00 - 13:00
Lunch break
13:00 - 14:30
Poster session 3
(odd poster numbers)
14:30 - 16:00
Session 3:
Cell and virus-based therapeutical developments (Experiences and recent developments with CAR-T cells in the clinic)
(Chair: Dirk Busch)
Early career investigator talk 6
Volker Morath /Munich [DE]
Seeing is believing: Imaging of cell and gene therapies using a novel PET reporter gene system
15:45 - 16:15
Marion Subklewe /Munich [DE]
RWE CD19 CART: Efficacy, Safety & Next Steps
16:15 - 16:45
Coffee break
09:00 - 10:30
Mini Symposium on Protein Engineering
(Chairs: Stefan Zielonka & Birte Höcker)
Introduction of the GBM Study Group "Protein Engineering & Design"
09:10 - 09:35
Stefan Zielonka /Darmstadt [DE]
Multi-functional NK cell engaging antibodies targeting EGFR and NKp30 elicit efficient tumor cell killing and pro-inflammatory cytokine release
10:30 - 12:15
Session 3:
Cell and virus-based therapeutical developments (Advanced lymphocyte and virus engineering technologies)
(Chair: Dirk Busch)
12:15 - 12:45
Junior GBM Session
(Chair: Nicola Bopp & Alexander Eing)
12:45 - 13:00
Poster prizes & closing remarks
Registration
Deadlines
Early registration: January 31
Standard registration: March 8
On site registration is possible.
Abstract submission: January 31
Sponsoring & Industrial Exhibition
If you wish to present your company at the 74th Mosbacher Kolloquium of the GBM please see the pricelist for sponsoring and the exhibition or contact
Dr. Anke Lischeid
GBM Managing Director
lischeid@gbm-online.de
Phone: +49 69 660567-12
Registration Fees
The registration fee includes coffee/tea/mineral water during the conference breaks.
Please note the general terms and conditions for payment and cancellation and our privacy policy.
If you want to join the GBM with your registration to enjoy the reduced participation fee, please fill in the online membership application (or fill the pdf application and send it to the GBM head office.
* member of the GBM, DECHEMA, DGZ, GDCh, VAAM, Bunsen Society
(Please bring a proof of your membership to the Kolloquium.)
| Non-members* | before Feb 1 |
before Mar 9 |
on site |
| Academia/ from Industry |
330 | 390 | 420 |
| PhD student | 150 | 185 | 200 |
| Bachelor/ Master student |
80 | 100 | 110 |
| Retiree | 80 | 100 | 110 |
All prices in EURO
| Members* | before Feb 1 |
before Mar 9 |
on site |
| Academia/ from Industry |
300 | 360 | 390 |
| PhD student | 140 | 175 | 190 |
| Bachelor/ Master student |
70 | 90 | 100 |
| Retiree | 70 | 90 | 100 |
All prices in EURO
We thank for the kind support by:
Main Sponsor:
Media Partner:
Sponsors:
Information
Accommodation
We do not have an overview of the current vacancies of the hotels in and around Mosbach. We therefore recommend booking via online portals such as booking.com or hotel.de.
The city of Mosbach publishes a list of hosts at https://www.mosbach.de
Abstracts
Please submit your abstract online after you finished the registration process.
All neccessary information will be provide during the abstract submission process.
In case you are preparing your abstract offline please mind the maximum length of 1500 characters.
Conference Proceedings
Your name badge and a program booklet will be available at the registration desk. Please wear your name badge during the whole meeting.
We do not provide a abstract book. Please download the abstract pdf shortly before the meeting or use the online list of abstracts in the program booklet
Covid 19
We will apply the Corona rules of the state of Baden-Württemberg in effect at the time of the meeting.
Grants
As a young member of the GBM you can apply for a travel grant (at the latest two months before the meeting) until February 15.
Still not a member of the GBM? Here you can apply for it.
Internet & Email
A wireless LAN connection is available within the foyer of the Alte Maelzerei.
Meals & Drinks
Coffee, tea and mineral water will be provided for free during the coffee breaks.
Lunch is available at your own expense in the conference center or at the restaurants nearby in the town of Mosbach.
Office
Numbers of the conference office (during the opening hours):
Tel. +49 6261 9292-78
Opening hours:
| Wednesday | 16:00 - 19:45 |
| Thursday | 08:00 - 17.:00 |
| Friday | 08:30 - 16:00 |
| Saturday | 08.30 - 11.00 |
Posters
The poster should be presented in portrait format (DIN A0 resp. ~120 x 85 cm). Posters should be presented throughout the whole meeting. The best three posters will be awarded at the end of the meeting with a price money of 300 € each.
Venue
Alte Mälzerei
Alte Bergsteige 7
74821 Mosbach
Visa
As a participant from abroad you may need a visa from the German embassy. If so please contact the meeting secretariat. We will send you the required invitation letter.
Organization & Contact
Contact
Meeting Secretariat:
Gesellschaft für Biochemie
und Molekularbiologie
Matthias Feige
Technical University of Munich [DE]
Dorothee Ambrosius
Boehringer-Ingelheim /Biberach [DE]
Dirk Busch
Technical University of Munich [DE]
Christian Klein
Roche Innovation Center /Zurich [CH]
