Cryo-EM and drug discovery
University of British Columbia, Vancouver, Canada
Recent breakthroughs in the field of cryo-electron microcopy (cryo-EM) provide new prospects for determination of the structures of a variety of medically important macromolecular assemblies. The prospect that the determination of protein structures at atomic resolution will no longer be limited by size, or by the need for crystallization represents a significant and exciting horizon in structural biology. In addition, advances in technologies for imaging viruses, cells and tissues in 3D have created new avenues for structural imaging in 3D and for integrating information across length scales. In my talk, I will discuss the broader context of the development of cryo-EM methods for studying large biological assemblies, and provide an overview of current progress and future directions as they relate to the development of improved therapeutic agents.